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Hitting the mother lode of tumor angiogenesis

An oral formulation of an antiangiogenic drug may allow long-term anti-cancer therapy.

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Figure 1: The structure of Lodamin enhances its bioavailability and stability in circulation and inhibits tumor growth and metastasis.

Kim Caesar

References

  1. Benny, O. Nat. Biotechnol. 26, 799–807 (2008).

    Article  CAS  Google Scholar 

  2. Folkman, J. N. Engl. J. Med. 285, 1182–1186 (1971).

    Article  CAS  Google Scholar 

  3. Hanahan, D. & Folkman, J. Cell 86, 353–364 (1996).

    Article  CAS  Google Scholar 

  4. Folkman, J. Nat. Rev. Drug Discov. 6, 273–286 (2007).

    Article  CAS  Google Scholar 

  5. Jain, R.K., Duda, D.G., Clark, J.W. & Loeffler, J.S. Nat. Clin. Pract. Oncol. 3, 24–40 (2006).

    Article  CAS  Google Scholar 

  6. Gasparini, G., Longo, R., Fanelli, M. & Teicher, B.A. J. Clin. Oncol. 23, 1295–1311 (2005).

    Article  CAS  Google Scholar 

  7. Thurston, G., Noguera-Troise, I. & Yancopoulos, G.D. Nat. Rev. Cancer 7, 327–331 (2007).

    Article  CAS  Google Scholar 

  8. Ingber, D. et al. Nature 348, 555–557 (1990).

    Article  CAS  Google Scholar 

  9. Bhargava, P. et al. Clin. Cancer Res. 5, 1989–1995 (1999).

    CAS  PubMed  Google Scholar 

  10. Satchi-Fainaro, R. et al. Nat. Med. 10, 255–261 (2004).

    Article  CAS  Google Scholar 

  11. Ferrara, N. & Kerbel, R.S. Nature 438, 967–974 (2005).

    Article  CAS  Google Scholar 

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James, D., Rabbany, S. & Rafii, S. Hitting the mother lode of tumor angiogenesis. Nat Biotechnol 26, 769–770 (2008). https://doi.org/10.1038/nbt0708-769

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