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An evolved ribosome for genetic code expansion

Directed evolution of an orthogonal ribosome improves the efficiency of unnatural amino acid incorporation in vivo.

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Figure 1: Strategy for site-specific insertion of amino acid analogs into proteins.

Kim Caesar

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Köhrer, C., RajBhandary, U. An evolved ribosome for genetic code expansion. Nat Biotechnol 25, 745–746 (2007). https://doi.org/10.1038/nbt0707-745

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