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Precision genome surgery

Nature Biotechnology volume 25, pages 743–744 (2007)Cite this article

A redesign of zinc-finger nucleases reduces off-target cleavage.

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Figure 1: Three approaches for cleaving DNA to increase the efficiency of homologous recombination for gene correction.

Kim Caesar

References

  1. Miller, J.C. et al. Nat. Biotechnol. 25, 778–785 (2007).

    Article  CAS  Google Scholar 

  2. Szczepek, M. et al. Nat. Biotechnol. 25, 786–793 (2007).

    Article  CAS  Google Scholar 

  3. Paques, F. & Duchateau, P. Curr. Gene Ther. 7, 49–66 (2007)

    Article  CAS  Google Scholar 

  4. Kim, Y.G., Cha, J. & Chandrasegaran, S. Proc. Natl. Acad. Sci USA 93, 1156–1160 (1996)

    Article  CAS  Google Scholar 

  5. Bitinaite, J., Wah, D.A., Aggarwal, A.K. & Schildkraut, I. Natl. Acad. Sci USA 95, 10550–10575 (1996)

    Google Scholar 

  6. Wah, D.A., Hirsch, J.A., Dorner, L.F., Schildkraut, I. & Aggarwal, A.K. Nature 388, 97–100 (1997)

    Article  CAS  Google Scholar 

  7. Arnould, S. et al. J. Mol. Biol. 355, 443–458 (2006)

    Article  CAS  Google Scholar 

  8. Silva, G. H, Wende, W. Belfort, M. & Pingoud, A. J. Mol. Biol. 361, 744–754 (2006)

    Article  CAS  Google Scholar 

  9. Duca et al. Nucl. Acids Res. 34, 1900–1911 (2006)

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Alfred Pingoud and George H. Silva are at the Institut fuer Biochemie, Fachbereich Biologie und Chemie, Justus-Liebig-Universitaet, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany. alfred.m.pingoud@chemie.bio.uni-giessen.de,

    Alfred Pingoud & George H Silva

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  1. Alfred Pingoud
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  2. George H Silva
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Pingoud, A., Silva, G. Precision genome surgery. Nat Biotechnol 25, 743–744 (2007). https://doi.org/10.1038/nbt0707-743

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