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Vectorology recapitulates virology—will it capitulate oncology?

Tumor-selective stabilization of RNA is employed as a new approach to engineer viruses that preferentially replicate in cancer cells.

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Figure 1: General oncolytic virus theory and models.

©Rebecca Henretta

References

  1. Ahmed, A. et al. Nat. Biotechnol. 21, 771–777 (2003).

    Article  CAS  Google Scholar 

  2. Smith, R. et al. Cancer 9, 1211–1218 (1956).

    Article  Google Scholar 

  3. Kirn, D. Oncogene 19, 6660–6669 (2000).

    Article  CAS  Google Scholar 

  4. Chiocca, E.A. Nat. Rev. Cancer 2, 938–951 (2002).

    Article  Google Scholar 

  5. Mullen, J.T. & Tanabe, K.K. The Oncologist 7, 106–119 (2002).

    Article  CAS  Google Scholar 

  6. Knipe, D.M. & Howley, P.M. (eds.). Fields Virology (Lippincott Williams & Wilkins, Philadelphia, Pennsylvania, USA, 2001).

    Google Scholar 

  7. Raghavan, A. et al. Nucleic Acids Res. 30, 5529–5538 (2002).

    Article  CAS  Google Scholar 

  8. Cumming, S.A. J. Virol. 76, 5993–6003 (2002).

    Article  CAS  Google Scholar 

  9. Nabors, L.B., Gillespie, G.Y., Harkins, L. & King, P.H. Cancer Res. 61, 2154–2161 (2001).

    CAS  PubMed  Google Scholar 

  10. Wein, M.L., Wu, J.T. & Kirn, D.H. Cancer Res. 63, 1317–1324 (2003).

    CAS  PubMed  Google Scholar 

  11. Harrison, D. et al. Hum. Gene Ther. 12, 1323–1332 (2001).

    Article  CAS  Google Scholar 

  12. Wakimoto, H., Johnson, P.R., Knipe, D.M. & Chiocca, E.A. Gene Ther. 10, 983–999 (2003).

    Article  CAS  Google Scholar 

  13. Toth, K. et al. Mol. Ther. 7, 435–437 (2003).

    Article  CAS  Google Scholar 

  14. Freytag, S. et al. Cancer Res. 62, 4968–4976 (2002).

    CAS  PubMed  Google Scholar 

Download references

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Aguilar-Cordova, E. Vectorology recapitulates virology—will it capitulate oncology?. Nat Biotechnol 21, 756–757 (2003). https://doi.org/10.1038/nbt0703-756

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