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Transplanting cloned cells into therapeutic promise

Nature Biotechnology volume 20, pages 665–666 (2002)Cite this article

Therapeutic cloning promises to provide genetically matched replacement tissue, but non-self mitochondrial proteins derived from the recipient oocyte could render cloned tissue immunogenic. A new study examines this issue.

Among the many obstacles that must be overcome to fulfill the oft-cited therapeutic promise of embryonic stem (ES) cells, one of the most important problems is histocompatibility: the degree to which foreign tissue is tolerated by the immune system of the recipient. Tissues derived from ES cells express foreign histocompatibility antigens, leading to their rejection by genetically disparate recipients. In this issue, a report by Lanza et al. indicates that somatic cell nuclear transfer may offer a solution to this problem1.

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Figure 1: Maternally transmitted antigens are determined by mitochondrial DNA.

© Bob Crimi

References

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Affiliations

  1. professor of surgery, Massachusetts General Hospital, Boston, 02114-3117, MA

    Hugh Auchincloss & Joseph V. Bonventre

  2. professor of medicine at Massachusetts General Hospital, Boston, 02114-3117, MA

    Joseph V. Bonventre

  3. codirector of the Harvard-MIT Division of Health Sciences and Technology

    Joseph V. Bonventre

Authors
  1. Hugh Auchincloss
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  2. Joseph V. Bonventre
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Auchincloss, H., Bonventre, J. Transplanting cloned cells into therapeutic promise. Nat Biotechnol 20, 665–666 (2002). https://doi.org/10.1038/nbt0702-665

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  • DOI: https://doi.org/10.1038/nbt0702-665

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