Crystal structures of a mammalian multidrug efflux pump bound to peptide inhibitors may reveal drug-binding sites.
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References
Gottesman, M. M. & Ling, V. FEBS Lett. 580, 998–1009 (2006).
Aller, S. G. et al. Science 323, 1718–1722 (2009).
Chen, C. J. et al. Cell 47, 381–389 (1986).
Gros, P., Croop, J. & Housman, D. Cell 47, 371–380 (1986).
Ambudkar, S. V. et al. Annu. Rev. Pharmacol. Toxicol. 39, 361–398 (1999).
Raviv, Y. et al. J. Biol. Chem. 265, 3975–3980 (1990).
Bruggemann, E. P., Germann, U. A., Gottesman, M. M. & Pastan, I. J. Biol. Chem. 264, 15483–15488 (1989).
Dey, S. et al. Proc. Natl. Acad. Sci. USA 94, 10594–10599 (1997).
Loo, T. W. & Clarke, D. M. Arch. Biochem. Biophys. 476, 51–64 (2008).
Dawson, R.J. & Locher, K. P. Nature 443, 180–185 (2006).
Tang-Wai, D. F. et al. Biochemistry 34, 32–39 (1995).
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Gottesman, M., Ambudkar, S. & Xia, D. Structure of a multidrug transporter. Nat Biotechnol 27, 546–547 (2009). https://doi.org/10.1038/nbt0609-546
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DOI: https://doi.org/10.1038/nbt0609-546
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