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Cause and express

Biological validation of a cadre of new obesity genes supports the power of studies that exploit 'expression quantitative trait loci'.

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Figure 1: Expression quantitative trait loci (eQTLs) are useful in understanding the molecular basis of complex diseases.

Katie Vicari


  1. Brem, R. B., Yvert, G., Clinton, R. & Kruglyak, L. Science 296, 752–755 (2002).

    Article  CAS  Google Scholar 

  2. Cookson, W., Liang, L., Abecasis, G., Moffatt, M. & Lathrop, M. Nat. Rev. Genet. 10, 184–194 (2009).

    Article  CAS  Google Scholar 

  3. Yang, X. et al. Nat. Genet. 41, 415–423 (2009).

    Article  CAS  Google Scholar 

  4. Rockman, M. V. & Kruglyak, L. Nat. Rev. Genet. 7, 862–872 (2006).

    Article  CAS  Google Scholar 

  5. Brem, R. B. & Kruglyak, L. Proc. Natl. Acad. Sci. USA 102, 1572–1577 (2005).

    Article  CAS  Google Scholar 

  6. Chen, L. S., Emmert-Streib, F. & Storey, J.D. Genome Biol. 8, R219 (2007).

    Article  Google Scholar 

  7. Zhu, J. et al. PLOS Comput. Biol. 3, e69 (2007).

    Article  Google Scholar 

  8. Yvert, G. et al. Nat. Genet. 35, 57–64 (2003).

    Article  CAS  Google Scholar 

  9. Katan, M. B. Lancet 1, 507–508 (1986).

    Article  CAS  Google Scholar 

  10. Davey Smith, G. & Ebrahim, S. Int. J. Epidemiol. 32, 1–22 (2003).

    Article  Google Scholar 

  11. Schadt, E. E. et al. Nat. Genet. 37, 710–717 (2005).

    Article  CAS  Google Scholar 

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Kruglyak, L., Storey, J. Cause and express. Nat Biotechnol 27, 544–545 (2009).

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