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Extrapolating from sequence—the 2009 H1N1 'swine' influenza virus

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Figure 1: Glycan-binding properties of Cal0409 HA.
Figure 2: Analysis of Cal0409 NA.


  1. Gamblin, S.J. et al. Science 303, 1838–1842 (2004).

    Article  CAS  Google Scholar 

  2. Taubenberger, J.K. et al. Nature 437, 889–893 (2005).

    Article  CAS  Google Scholar 

  3. Tumpey, T.M. et al. Science 310, 77–80 (2005).

    Article  CAS  Google Scholar 

  4. Palese, P., Tumpey, T.M. & Garcia-Sastre, A. Immunity 24, 121–124 (2006).

    Article  CAS  Google Scholar 

  5. Stevens, J. et al. J. Mol. Biol. 355, 1143–1155 (2006).

    Article  CAS  Google Scholar 

  6. Tumpey, T.M. et al. Science 315, 655–659 (2007).

    Article  CAS  Google Scholar 

  7. Pappas, C. et al. Proc. Natl. Acad. Sci. USA 105, 3064–3069 (2008).

    Article  CAS  Google Scholar 

  8. Srinivasan, A. et al. Proc. Natl. Acad. Sci. USA 105, 2800–2805 (2008).

    Article  CAS  Google Scholar 

  9. Van Hoeven, N. et al. Proc. Natl. Acad. Sci. USA 106, 3366–3371 (2009).

    Article  CAS  Google Scholar 

  10. Chandrasekaran, A. et al. Nat. Biotechnol. 26, 107–113 (2008).

    Article  CAS  Google Scholar 

  11. Fanning, T.G., Reid, A.H. & Taubenberger, J.K. Virology 276, 417–423 (2000).

    Article  CAS  Google Scholar 

  12. Dharan, N.J. et al. J. Am. Med. Assoc. 301, 1034–1041 (2009).

    Article  CAS  Google Scholar 

  13. Collins, P.J. et al. Nature 453, 1258–1261 (2008).

    Article  CAS  Google Scholar 

  14. Stouffer, A.L. et al. Nature 451, 596–599 (2008).

    Article  CAS  Google Scholar 

  15. Pielak, R.M., Schnell, J.R. & Chou, J.J. Proc. Natl. Acad. Sci. USA 106, 7379–7384 (2009).

    Article  CAS  Google Scholar 

  16. Gubareva, L. et al. Morb. Mortal Wkly. Rep. 58, 433–435 (2009).

    Google Scholar 

  17. Fiore, A.E. et al. MMWR Recomm. Rep. 57, 1–60 (2008).

    PubMed  Google Scholar 

  18. Fraser, C. et al. Science DOI: 10.1126/science.1176062, May 14, 2009.

    Article  CAS  Google Scholar 

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The authors would like to acknowledge support from the Singapore–Massachusetts Institute of Technology Alliance for Research and Technology; and the National Institute of General Medical Sciences of the National Institutes of Health (GM 57073 andU54 GM62116) to R.S.

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Correspondence to Ram Sasisekharan.

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Soundararajan, V., Tharakaraman, K., Raman, R. et al. Extrapolating from sequence—the 2009 H1N1 'swine' influenza virus. Nat Biotechnol 27, 510–513 (2009).

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