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Proteases' prime targets revealed

Nature Biotechnology volume 26, pages 652–653 (2008)Cite this article

Mass spectrometry analysis of proteome-derived peptide libraries enables high-throughput determination of protease substrate specificity.

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Figure 1: Proteomic identification of protease cleavage sites (PICS) determines the substrate specificity of a protease using diverse libraries of potential substrates derived from natural proteomes.

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Authors and Affiliations

  1. Scott L. Diamond and Doron Greenbaum are in the Departments of Chemical Engineering and Bioengineering, University of Pennsylvania, 1024 Vagelos Research Laboratories, Philadelphia, Pennsylvania 19104-6383, USA. sld@seas.upenn.edu,

    Scott L Diamond & Doron Greenbaum

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  1. Scott L Diamond
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  2. Doron Greenbaum
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Diamond, S., Greenbaum, D. Proteases' prime targets revealed. Nat Biotechnol 26, 652–653 (2008). https://doi.org/10.1038/nbt0608-652

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