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Assisted suicide for retroviruses

Antisense oligonucleotides activate the self-destruction of retroviruses in vivo.

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Figure 1: Steps in the reverse transcription of retroviral RNA (red) to produce double-stranded DNA (dark and light blue), and the site of interference by oligodeoxynucleotides targeted to the polypurine tract.


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Johnson, W. Assisted suicide for retroviruses. Nat Biotechnol 25, 643–644 (2007).

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