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DNA synthesis and biological security

A group of academics, industry executives and security experts propose an oversight framework to address concerns over the security of research involving commercial DNA synthesis.

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Figure 1: Our framework calls for the immediate and systematic implementation of a tiered DNA synthesis order screening process.


  1. Baker, D. et al. Sci. Am. 294, 44–51 (2006).

    CAS  Article  Google Scholar 

  2. Endy, D. et al. A Practical Perspective on DNA Synthesis and Biological Security, published online 4 December 2006 <>

    Google Scholar 

  3. Church, G. A Synthetic Biohazard Non-proliferation Proposal, published online 18 June 2004; updated 21 May 2005 <>

    Google Scholar 

  4. Public Draft of the Declaration of the Second International Meeting on Synthetic Biology, published online 30 May 2006 <>

  5. Etc. Group. Extreme Genetic Engineering: An Introduction to Synthetic Biology, published online January 2007 <>

  6. Check, E. Nature 436, 894–895 (2005).

    CAS  Article  Google Scholar 

  7. <>

  8. Cohen, S.N., Chang, A.C., Boyer, H.W. & Helling, R.B. Proc. Natl. Acad. Sci. USA. 70, 3240–3244 (1973).

    CAS  Article  Google Scholar 

  9. Gefter, M.L., Molineux, I.J., Kornberg, T. & Khorana, H.G. J. Biol. Chem. 247, 3321–3326 (1972).

    CAS  PubMed  Google Scholar 

  10. Mullis, K. et al. Cold Spring Harb. Symp. Quant. Biol. 51, 263–273 (1986).

    Google Scholar 

  11. Berg, P., Baltimore, D., Brenner, S., Roblin, R.O. & Singer, M.F. Proc. Natl. Acad. Sci. USA. 72, 1981–1984 (1975).

    CAS  Article  Google Scholar 

  12. Carlson, R. Biosecur. Bioterror. 1, 203–214 (2003).

    Article  Google Scholar 

  13. Carlson, R. & Church, G.M. Wired 13, 12–16 (2005).

    Google Scholar 

  14. 18 U.S.C. § 2332a

  15. Baric, R.S. et al. Adv. Exp. Med. Biol. 581, 553–560 (2006).

    CAS  Article  Google Scholar 

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The article expresses the opinions of the individual authors and does not necessarily reflect US government policy. We thank colleagues serving on the US National Science Advisory Board for Biosecurity, other government agencies and the organizers and participants in a project supported by the Alfred P. Sloan Foundation for sharing information and perspectives that directly inform our Commentary.

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H.B., R.W., GENEART; J.P.D., G.C., D.E., Codon Devices; J.M., Blue Heron Biotechnologies; R.M., D.R., CODA Genomics; H.-O. P., Bioneer; B.R., BaseClear.

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Bügl, H., Danner, J., Molinari, R. et al. DNA synthesis and biological security. Nat Biotechnol 25, 627–629 (2007).

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