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Alginate Biosynthesis: A Model System for Gene Regulation and Function in Pseudomonas

Bio/Technologyvolume 5pages469477 (1987) | Download Citation

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Abstract

Alginate is an exopolysaccharide of industrial and medical importance. Understanding the biochemistry, genetics and molecular biology of alginate biosynthesis by P. aeruginosa is undergoing rapid development. The alginate biosynthetic pathway has been partially deduced. Transcriptional activation of alginate gene(s) appears to be a critical step in the establishment of mucoidy. Studies on the regulation and function of the alg gene complex will significantly increase our knowledge of gene expression in Pseudomonas, and hopefully allow better control of the proliferation of mucoid strains in Cystic Fibrosis patients.

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  1. Department of Microbiology and Immunology, Health Sciences Center, University of Illinois at Chicago, Chicago, IL, 60612

    • V. Deretic
    • , J. F. Gill
    •  & A. M. Chakrabarty

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https://doi.org/10.1038/nbt0587-469

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