Commentary | Published:

Next-generation biomarkers for detecting kidney toxicity

Nature Biotechnology volume 28, pages 436440 (2010) | Download Citation

There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.

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Author information

Affiliations

  1. Joseph V. Bonventre and Vishal S. Vaidya are in the Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA;

    • Joseph V Bonventre
    •  & Vishal S Vaidya
  2. Robert Schmouder is in Translational Sciences, Novartis Institutes for BioMedical Research, East Hanover, New Jersey, USA;

    • Robert Schmouder
  3. Peter Feig is in Cardiovascular Clinical Research, Merck Research Laboratories, Rahway, New Jersey, USA;

    • Peter Feig
  4. Frank Dieterle is in Translational Sciences, Novartis Institutes for BioMedical Research, Basel, Switzerland.

    • Frank Dieterle

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Competing interests

R.S. and F.D. are employees of Novartis and P.F. is an employee of Merck.

Corresponding author

Correspondence to Joseph V Bonventre.

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DOI

https://doi.org/10.1038/nbt0510-436

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