Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Targeted instant immunity

Antibodies can be programmed to bind cancer cells using covalently binding antigens and adapters.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Chemical programming redirects covalently binding antibodies to reduce tumor progression.

Katie Vicari

References

  1. 1

    Popkov, M., Gonzalez, B., Sinha, S.C. & Barbas, C.F. III. Proc. Natl. Acad. Sci. USA 106, 4378–4383 (2009).

    CAS  Article  Google Scholar 

  2. 2

    Rader, C. et al. Proc. Natl. Acad. Sci. USA 100, 5396–5400 (2003).

    CAS  Article  Google Scholar 

  3. 3

    Li, L.-S. et al. J. Med. Chem. 47, 5630–5640 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Guo, F. et al. Proc. Natl. Acad. Sci. USA 103, 11009–11014 (2006).

    CAS  Article  Google Scholar 

  5. 5

    Popkov, M. et al. Int. J. Cancer 119, 1194–1207 (2006).

    CAS  Article  Google Scholar 

  6. 6

    Doppalapudi, V.R. et al. Bioorg. Med. Chem. Lett. 17, 501–506 (2007).

    CAS  Article  Google Scholar 

  7. 7

    Lu, Y. & Low, P.S. Cancer Immunol. Immunother. 51, 153–162 (2002).

    CAS  Article  Google Scholar 

  8. 8

    Shokat, K.M. & Schultz, P.G. J. Am. Chem. Soc. 113, 1861–1862 (1991).

    CAS  Article  Google Scholar 

  9. 9

    Mullis, K.B. Chemically programmable immunity. US patent 7,422,746 (2008).

  10. 10

    Bertozzi, C.R. & Bednarski, M.D. J. Am. Chem. Soc. 114, 5543–5546 (1992).

    CAS  Article  Google Scholar 

  11. 11

    Naicker, K.P. et al. Org. Biomol. Chem. 2, 660–664 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Meares, C. Targeted instant immunity. Nat Biotechnol 27, 452–453 (2009). https://doi.org/10.1038/nbt0509-452

Download citation

Search

Quick links