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Overcoming the gridlock in discovery research

Chemical screening in a zebrafish mutant has turned up two compounds that rescue a heart defect, but will this yield new drugs?

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Figure 1: Gridlock positively regulates arterial differentiation of angioblast progenitors in the developing vascular system.

Bob Crimi


  1. 1

    Peterson R.T. et al. Nat. Biotechnol. 22, 595–599 (2004).

    CAS  Article  Google Scholar 

  2. 2

    Mayer, T.U. et al. Science 286, 971–974 (1999).

    CAS  Article  Google Scholar 

  3. 3

    Stern, H.M. et al. Patent application WO03052106 (2004).

  4. 4

    Peterson, R.T. et al. Proc. Natl. Acad. Sci. USA 97, 12965–12969 (2000).

    CAS  Article  Google Scholar 

  5. 5

    Clader, J.W. J. Med. Chem. 47, 1–9 (2004).

    CAS  Article  Google Scholar 

  6. 6

    Schafer, G. Diabetes Metab. 9, 148–163 (1983).

    CAS  Google Scholar 

  7. 7

    Kothari, S.A. et al. J. Thromb. Thrombolysis 15, 217–225 (2003).

    CAS  Article  Google Scholar 

  8. 8

    Service, R.F. Science 303, 1798 (2004).

    Article  Google Scholar 

  9. 9

    Margolis, J. & Duyk, G. Nat. Biotechnol. 16, 311 (1998).

    CAS  Article  Google Scholar 

  10. 10

    Fischer, A. & Gessler, M. Trends Cardiovasc. Med. 6, 221–226 (2003).

    Article  Google Scholar 

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Margolis, J., Plowman, G. Overcoming the gridlock in discovery research. Nat Biotechnol 22, 522–524 (2004).

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