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Overcoming the gridlock in discovery research

Chemical screening in a zebrafish mutant has turned up two compounds that rescue a heart defect, but will this yield new drugs?

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Figure 1: Gridlock positively regulates arterial differentiation of angioblast progenitors in the developing vascular system.

Bob Crimi

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Margolis, J., Plowman, G. Overcoming the gridlock in discovery research. Nat Biotechnol 22, 522–524 (2004). https://doi.org/10.1038/nbt0504-522

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