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Bringing picomolar protein detection into proximity

Nature Biotechnology volume 20, pages 448–449 (2002)Cite this article

Combining target recognition by two aptamers, enzymatic ligation, and PCR, the proximity ligation method enables the detection of minute amounts of proteins.

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Figure 1: The proximity ligation assay can be 1,000-fold more sensitive than a conventional ELISA.

© Bob Crimi

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  1. professor at the Kekulé Institute of Organic Chemistry and Biochemistry, Universität Bonn, Gerhard-Domagk-Strasse 1, Bonn, 53121, Germany

    Michael Famulok

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  1. Michael Famulok
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Famulok, M. Bringing picomolar protein detection into proximity. Nat Biotechnol 20, 448–449 (2002). https://doi.org/10.1038/nbt0502-448

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