Abstract
We have prepared a robust polymer that can be used to measure glucose concentrations in complex biological media. At alkaline pH, the metal-complexing polymer binds glucose and instantly releases protons in proportion to the glucose concentration over a clinically relevant range (0 to 25 mM). The inexpensive polymer is sufficiently selective to provide an easily measurable response to glucose in porcine plasma. The polymer's ability to function at nonphysiological pH (at which the buffer capacity of biological samples is small) makes it possible to design simple and inexpensive sensing devices based on measurement of changes in proton concentration.
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Chen, G., Guan, Z., Chen, CT. et al. A glucose-sensing polymer. Nat Biotechnol 15, 354–357 (1997). https://doi.org/10.1038/nbt0497-354
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DOI: https://doi.org/10.1038/nbt0497-354
