Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

RNase P in Research and Therapy

Bio/Technology volume 13, pages 327–329 (1995)Cite this article

Abstract

Fooling the catalytic RNA subunit into recognizing nonnatural substrates may have important implications for biotech

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Doersen, C.-J., Guerrier-Takada, C., Altman, S. and Attardi, G. 1985. Characterization of an RNase P activity from HeLa cell mitochondria: Comparison with cytosol RNase P. J. Biol. Chem 260: 5942–5949.

    CAS  PubMed  Google Scholar 

  2. McClain, W.H., Guerrier-Takada, C. and Altman,S. 1987. Model substrates for an RNA enzyme. Science 238: 527–530

    Article  CAS  Google Scholar 

  3. Forster, A.C. and Altman, S. 1990. External guide sequences for an RNA enzyme. Science 249: 783–786.

    Article  CAS  Google Scholar 

  4. Li, Y., Guerrier-Takada, C. and Altman, S. 1992. Targeted cleavage of mRNA in vitro by RNase P from Escherichia coli. Proc. Natl. Acad. Sci. USA. 89: 3185–3189

    Article  CAS  Google Scholar 

  5. Guerrier-Takada, C., Li, Y. and Altman, S. in preparation.

  6. Yuan, Y., Hwang, E.-S. and Altman, S. 1992. Targeted cleavage of mRNA by human RNase P. Proc. Natl. Acad. Sci. USA. 89: 8006–8010.

    Article  CAS  Google Scholar 

  7. Yuan, Y. and Altman, S. 1994. Selection of guide sequences that direct efficient cleavage of mRNA by human ribonuclease P. Science 263: 1269–1273.

    Article  CAS  Google Scholar 

  8. Liu, F. and Altman, S. unpublished experiments.

  9. Plehn-Dujowich, D., Krug, R. and Altman, S. 1995. unpublished experiments.

  10. Liu, F. and Altman, S. unpublished experiments.

  11. Liu, F. and Altman, S. Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli. Genes and Development, in press.

  12. Frank, D., Harris, M. and Pace, N.R. 1994. Rational design of self-cleaving pre-tRNA-ribonuclease P RNA conjugates. Biochemistry 33: 10800–10808

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Sidney Altman: This article was excerpted from Dr. Altman's Feodor Lynen Lecture, which he delivered jointly with Dr. Thomas Cech at the Miami Bio/Technology Winter Symposium, Fort Lauderdale, FL, in February.

Authors and Affiliations

  1. Sterling Professor of Biology at Yale University, Kline Biology Tower, 219 Prospect St., New Haven, CT, 06511

    Sidney Altman

Authors
  1. Sidney Altman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Altman, S. RNase P in Research and Therapy. Nat Biotechnol 13, 327–329 (1995). https://doi.org/10.1038/nbt0495-327

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0495-327

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing