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Locking in on the human methylome

Two groups have combined padlock probes and massively parallel sequencing to characterize cytosine methylation in targeted regions of the human genome.

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Figure 1: High-throughput analysis of genomic methylation using padlock probes and bisulfite-treated DNA3,4 or methylation-sensitive cut counting4.


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Competing interests

P.W.L. is a Scientific Advisory Board member and consultant for Epigenomics, AG, which has a commercial interest in DNA methylation diagnostics.

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Berman, B., Weisenberger, D. & Laird, P. Locking in on the human methylome. Nat Biotechnol 27, 341–342 (2009).

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