Taming ricin toxin

An immunotoxin is made safer by the introduction of a point mutation.

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Figure 1: The recombinant A chain of ricin toxin is missing the B domain needed to bind to cells, but can be directed to kill cancer cells by connecting it to a monoclonal antibody that binds to a tumor antigen.

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Kreitman, R. Taming ricin toxin. Nat Biotechnol 21, 372–374 (2003). https://doi.org/10.1038/nbt0403-372

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