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DNA sandwiches with silver and gold

Can DNA hybridization be exploited to create electrical circuits for the detection of DNA sequence variants?

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Figure 1: Principle for distinguishing sequence variants by sandwich hybridization and electrical detection of nanoparticle probes.

© Bob Crimi

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Syvänen, AC., Söderlund, H. DNA sandwiches with silver and gold. Nat Biotechnol 20, 349–350 (2002). https://doi.org/10.1038/nbt0402-349

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