Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Septic Shock What Do Physicians Want?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bone, R.C. 1991. The pathogenesis of sepsis. Ann. Intern. Med. 115: 457–469.

    Article  CAS  PubMed  Google Scholar 

  2. Bone, R.C. 1991. Multiple system organ failure and the sepsis syndrome. Hospital Practice. Nov. 15.

  3. Natanson, C., Danner, R.L., Reilly, J.M., Doerfler, M.L., Hoffman, W.D., Akin, G.L. et al. 1990. Antibiotics versus cardiovascular support in a canine model of human septic shock. Am. J. Physiol. 259(5Pt.2):-H1440–1447.

    CAS  PubMed  Google Scholar 

  4. Parillo, J.E., Parker, M.M., Natanson, C., Suffredini, A.F., Danner, R.L., Cunnion, R.E., et al. 1990. HIH Conference. Septic shock in humans: Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann. Intern. Med. 113: 227–242.

    Article  Google Scholar 

  5. Friedman, R. 1991. Doctor's dilemma with sepsis drugs. Bio World Today 2: 1.

    Google Scholar 

  6. Schulman, K.A., Glick, H.A., Rubin, H., Eisenberg, J.M. 1991. Cost-effectiveness of HA-1A monoclonal antibody for Gram-negative sepsis: Economic assessment of a new therapeutic agent. JAMA 266: 3466–3471.

    Article  CAS  PubMed  Google Scholar 

  7. Rackow, E.C., Asitz, M.E. 1991. Patho-physiology and treatment of septic shock. JAMA 266: 548–554.

    Article  CAS  PubMed  Google Scholar 

  8. Springer, T.A. 1990. Adhesion receptors of the immune system. Nature 346: 425–427.

    Article  CAS  PubMed  Google Scholar 

  9. Smith, C.W., Kishimoto, T.K., Aggass, O., Hughes, B., Rothlein, R., Mclntire, L.V., Butcher, E., Anderson, D.C. et al. 1991. Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-l)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro. J. Clin. Invest. 87: 609–618.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Picker, L.J., Warnock, R.A., Burns, A.R., Doerschoek, C.M., Berg, E.L., Butcher, E.C. 1991. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 66: 921–933.

    Article  CAS  PubMed  Google Scholar 

  11. Luscinskas, F.W., Cybulsky, M.I., Kiely, J.M., Peckins, C.S., Davis, V.M., Gimbrone, M.A. 1991. Cytokine-activated human endothelial monolayers supportenhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. J. Immunol. 146: 1617–1625.

    CAS  PubMed  Google Scholar 

  12. Mulligan, M.S., Varani, J., Dame, M.K., Lane, C.L., Smith, C.W. 1991. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediatedlung injury in rats. J. Clin. Invest. 88: 1396–1406.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Huber, A.R., Kunkel, S.L., Todd, R.F., Weiss, S.J. 1991. Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 254: 99–102.

    Article  CAS  PubMed  Google Scholar 

  14. Dinarello, C.A. 1991. The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. J. Inf. Dis. 163: 1177–1184.

    Article  CAS  Google Scholar 

  15. Bochner, B.S., Luscinskas, F.W., Gimbrone, M.A., Newman, W., Sterbinsky, S.A., Derse-Anthony, C.P., Klunk, D., Schleimer, R.P. 1991. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: Contributions of endothelial cell adhesion molecules. J. Exp. Med. 173: 1553–1556.

    Article  CAS  PubMed  Google Scholar 

  16. Kuijpers, T.W., Hakkert, B.C., Hoogerwerf, M., Leeuwenberg, J.F.M., Roos, D. 1991. Role of endothelial leukocyte adhesion molecule-1 and platelet-activating factor in neutrophil adherence ti IL-1-prestimulated endothelial cells. J. Immunol. 147: 1369–1376.

    CAS  PubMed  Google Scholar 

  17. Kishimoto, T.K., Warnock, A., Jutila, M.A., Butcher, E.C., Lane, C., Anderson, D.C., Smith, W.C. 1991. Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78: 805–811.

    CAS  PubMed  Google Scholar 

  18. Lobb, R.R., Chi-Rosso, G., Leone, D.R., Rosa, M.D., Bixler, S., Newman, B.M., Luhowskyj, S., Benjamin, C.D., Dougas, I.G., Goelz, S.E., Hession, C., Chow, E.P. 1991. Expression and functional characterization of a soluble form of endothelial leukocyte adhesion molecule 1. J. Immunol. 147: 124–129.

    CAS  PubMed  Google Scholar 

  19. Tiemeyer, M., Swiedler, S.J., Ishihara, M., Moreland, M., Schweingruber, H., Hirtzer, P., Brandley, B.K. 1991. Carbohydrate ligands for endothelial-leukocyte adhesion molecule-1. Proc. Natl. Acad. Sri. USA. 88: 1138–1142.

    Article  CAS  Google Scholar 

  20. Phillips, M.L., Nudelman, E., Caeta, F.C.A., Perez, M., Singhal, A.K., Hakomori, S.I., Paulson, J.C. 1990. ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, Sialyl-Le. Science 250: 1130–1132.

    Article  CAS  PubMed  Google Scholar 

  21. Ashkenazi, A., Marsters, S.A., Capon, D.J., Chamow, S.M., Figari, I.S., Pennica, D., Goeddel, D.V., Palladino, M.A., Smith, D.H. 1991. Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. Proc. Natl. Acad. Sci. USA 88: 10535–10539.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schmeichel, C., McCormick, D. Septic Shock What Do Physicians Want?. Nat Biotechnol 10, 264–267 (1992). https://doi.org/10.1038/nbt0392-264

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0392-264

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing