Citrus breeders Fred Gmitter (left) and Chunxian Chen at the University of Florida's Citrus Research and Education Center display new varieties of grapefruit and pomelo hybrids that could resolve the problem of grapefruit/drug interactions. The team developed the hybrid fruit as a cross between grapefruit and pummelo, a citrus species native to Southeast Asia. The hybrid, known as UF 914, has extremely low furanocoumarin content, which is thought to interfere with cytochrome P450 A34 enzyme involved in drug metabolism and P-glycoprotein.