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Overhauling clinical trials

Designing clinical trials that adapt midstream is billed as a cure for drug development blues, one that can save time, money and improve patients' lives. Are these new designs safe and effective or an expensive gimmick?

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Figure 1: Percentage of terminated projects by phase (1994–2005).
Figure 2: Perceived barriers to adaptive trials.


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Scott, C., Baker, M. Overhauling clinical trials. Nat Biotechnol 25, 287–292 (2007).

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