Knockdown by RNAi—proceed with caution

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Small interfering RNAs, synthesized using phage polymerases but not by chemical methods, can trigger the interferon response in mammalian cells.

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Figure 1: Mechanisms by which dsRNA functions as a molecular trigger to mediate changes in gene expression patterns.

Bob Crimi

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Samuel, C. Knockdown by RNAi—proceed with caution. Nat Biotechnol 22, 280–282 (2004) doi:10.1038/nbt0304-280

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