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A solid base for assaying protein kinase activity

Peptide chips enable quantitative analysis of protein kinase activity and should facilitate the search for novel classes of protein kinase inhibitors.

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Figure 1: A schematic diagram of a chip used for monitoring protein kinase activity.

© Bob Crimi

References

  1. Plowman, G.D. et al. Proc. Natl. Acad. Sci. USA 96, 36603–13610 (1999).

    Article  Google Scholar 

  2. Houseman, B.T., Huh, J.H., Kron, S.J. & Mrksich, M. Nat. Biotechnol. 20, 270–274 (2002).

    Article  CAS  Google Scholar 

  3. Schlessinger, J. Cell 103, 211–225 (2000).

    Article  CAS  Google Scholar 

  4. Zheng J. et al. Biochemistry 32, 2154–2161 (1993).

    Article  CAS  Google Scholar 

  5. Mohammadi, M. et al. Science 276, 955–960 (1997).

    Article  CAS  Google Scholar 

  6. Mohammadi, M. et al. EMBO J. 17, 5896–5904 (1998).

    Article  CAS  Google Scholar 

  7. Mrksich, M. & Whitesides, G.M. Annu. Rev. Biophy. Biomol. Structure 25, 55–78 (1996).

    Article  CAS  Google Scholar 

  8. Zhu, H. et al. Science 293, 2101–2105 (2001).

    Article  CAS  Google Scholar 

  9. Zhu, H. et al. Nature Genet. 26, 283–299 (2002).

    Article  Google Scholar 

Download references

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Schlessinger, J. A solid base for assaying protein kinase activity. Nat Biotechnol 20, 232–233 (2002). https://doi.org/10.1038/nbt0302-232

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