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The delivery of angiogenic factors to the heart by microsphere therapy

Nature Biotechnology volume 16, pages 159–162 (1998)Cite this article

Abstract

Microspheres offer the possibility of local noninvasive delivery of drugs over an extended period of time. We adsorbed fibroblast growth factor (FGF) to microspheres of precapillary size that were injected via a coronary catheter. We showed that FGF was released from these microspheres and taken up by endothelial cells, which proliferated following translocation of FGF to the nucleus. This method for application of growth factors allows the precise delivery of angiogenic substances to any selected part of the heart or other organs without causing inflammation or ischemia.

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Authors and Affiliations

  1. Max-Planck-Institute for Physiological and Clinical Research, Department of Experimental Cardiology, Benekestrasse 2, D-61231, Bad Nauheim, Germany

    Margarete Arras, Hanke Mollnau, Rudolf Strasser, Wulf Ito, Jutta Schaper & Wolfgang Schaper

  2. Merck Biomaterials, Merck KGaA, Darmstadt, Germany

    Robert Wenz

Authors
  1. Margarete Arras
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  2. Hanke Mollnau
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  4. Robert Wenz
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  5. Wulf Ito
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  6. Jutta Schaper
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  7. Wolfgang Schaper
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Correspondence to Wulf Ito.

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Arras, M., Mollnau, H., Strasser, R. et al. The delivery of angiogenic factors to the heart by microsphere therapy. Nat Biotechnol 16, 159–162 (1998). https://doi.org/10.1038/nbt0298-159

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