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Systematic tracking of cell fate changes

High-throughput measurements across several regulatory levels provide a comprehensive view of ES-cell differentiation.

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Figure 1: Systematic monitoring of differentiating ES cells.


  1. Lu, R. et al. Nature 462, 358–362 (2009).

    Article  CAS  Google Scholar 

  2. MacArthur, B.D., Ma'ayan, A. & Lemischka, I.R. Cold Spring Harb. Symp. Quant. Biol. 73, 211–215 (2008).

    Article  CAS  Google Scholar 

  3. Mitsui, K. et al. Cell 113, 631–642 (2003).

    Article  CAS  Google Scholar 

  4. Chambers, I. et al. Cell 113, 643–655 (2003).

    Article  CAS  Google Scholar 

  5. de Sousa Abreu, R., Penalva, L.O., Marcotte, E.M. & Vogel, C. Mol. Biosyst. 5, 1512–1526 (2009).

    PubMed  Google Scholar 

  6. MacArthur, B.D., Lachmann, A., Lemischka, I.R. & Ma'ayan, A. Bioinformatics 26, 143–144 (2010).

    Article  CAS  Google Scholar 

  7. Marson, A. et al. Cell 134, 521–533 (2008).

    Article  CAS  Google Scholar 

  8. Singh, A.M., Hamazaki, T., Hankowski, K.E. & Terada, N. Stem Cells 25, 2534–2542 (2007).

    Article  CAS  Google Scholar 

  9. Chambers, I. et al. Nature 450, 1230–1234 (2007).

    Article  CAS  Google Scholar 

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Correspondence to Stuart H Orkin.

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The authors declare no competing financial interests.

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Kim, J., Orkin, S. Systematic tracking of cell fate changes. Nat Biotechnol 28, 146–147 (2010).

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