Metabolic engineering on a grand scale has produced yeast that can synthesize hydrocortisone.
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Kelly, D., Kelly, S. Rewiring yeast for drug synthesis. Nat Biotechnol 21, 133–134 (2003). https://doi.org/10.1038/nbt0203-133
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DOI: https://doi.org/10.1038/nbt0203-133
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