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T-Cell Recognition of Proteins: Conclusions From the Localization of the Full T-Cell Recognition Profiles of Two Native Proteins

Bio/Technologyvolume 3pages4754 (1985) | Download Citation

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Abstract

Previous studies from this laboratory were the first to define all the sites recognized by antibodies (i.e. antigenic sites) in several protein antigens. Recently, using a comprehensive synthetic strategy, we have scanned the entire polypeptide chains of myoglobin and lysozyme and have determined the full profile of the continuous sites of T-cell recognition for each protein. Together, these studies have enabled the first detailed comparison, at the sub-molecular level, of the protein regions involved in T- and B-cell recognition.

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  1. Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX, 77030

    • Garvin S. Bixler Jr.
    •  & M. Zouhair Atassi

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https://doi.org/10.1038/nbt0185-47