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Genome sequencing on nanoballs

Nature Biotechnology volume 28, pages 43–44 (2010)Cite this article

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Advances in technology deliver cheaper human genome sequencing.

The rapid pace of innovation in the field of genome sequencing continues with a recent publication in Science by Drmanac et al.1. The authors resequenced three full human genomes using a next-generation technology that combines highly efficient imaging on ordered arrays with an inexpensive ligation-based chemistry. These technological improvements further reduce the cost of human genome sequencing.

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Figure 1: Comparison of the sequencing process in Drmanac et al.1 (left) and in a previous sequencing-by-ligation method2 (right).

References

  1. Drmanac, R. et al. Science, published online doi:10.0026/science.1181498 (5 November 2009). 2009 Nov 5 [Epub ahead of print]

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  1. Gregory J. Porreca is at Good Start Genetics, Boston, MA.,

    Gregory J Porreca

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  1. Gregory J Porreca
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Correspondence to Gregory J Porreca.

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Competing interests

G.J.P. is an employee of, and holds stock in, Good Start Genetics, Inc. He is listed as an inventor on patents and patent applications related to next-generation sequencing technology, and is eligible to receive royalty distributions under the assignee's royalty-sharing policy.

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Porreca, G. Genome sequencing on nanoballs. Nat Biotechnol 28, 43–44 (2010). https://doi.org/10.1038/nbt0110-43

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