Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Putting the lid on phosphodiesterase 4

Structural insights into the regulation of phosphodiesterase 4 lead to the discovery of allosteric modulators with reduced side effects.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Structural basis of PDE4 regulation.


  1. 1

    Conti, M. & Beavo, J. Annu. Rev. Biochem. 76, 481–511 (2007).

    CAS  Article  Google Scholar 

  2. 2

    Houslay, M.D., Baillie, G.S. & Maurice, D.H. Circ. Res. 100, 950–966 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Houslay, M.D., Schafer, P. & Zhang, K.Y. Drug Discov Today 10, 1503–1519 (2005).

    CAS  Article  Google Scholar 

  4. 4

    Burgin, A. et al. Nat. Biotechnol. 27, 63–70 (2010).

    Article  Google Scholar 

  5. 5

    Beard, M.B. et al. J. Biol. Chem. 275, 10349–10358 (2000).

    CAS  Article  Google Scholar 

  6. 6

    Lim, J., Pahlke, G. & Conti, M. J. Biol. Chem. 274, 19677–19685 (1999).

    CAS  Article  Google Scholar 

  7. 7

    Xu, R.X. et al. Science 288, 1822–1825 (2000).

    CAS  Article  Google Scholar 

  8. 8

    Wang, H. et al. Biochem. J. 408, 193–201, (2007).

    CAS  Article  Google Scholar 

  9. 9

    McPhee, I. et al. J. Biol. Chem. 274, 11796–11810 (1999).

    CAS  Article  Google Scholar 

  10. 10

    Bolger, G.B. et al. Biochem. J. 398, 23–36, (2006).

    CAS  Article  Google Scholar 

  11. 11

    Terry, R. et al., Cell. Signal. 15, 955–971 (2003)

    CAS  Article  Google Scholar 

  12. 12

    Robichaud, A. et al. J. Clin. Invest. 110, 1045–1052 (2002).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Miles D Houslay.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Houslay, M., Adams, D. Putting the lid on phosphodiesterase 4. Nat Biotechnol 28, 38–40 (2010).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing