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Putting the lid on phosphodiesterase 4

Structural insights into the regulation of phosphodiesterase 4 lead to the discovery of allosteric modulators with reduced side effects.

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Figure 1: Structural basis of PDE4 regulation.

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Correspondence to Miles D Houslay.

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Houslay, M., Adams, D. Putting the lid on phosphodiesterase 4. Nat Biotechnol 28, 38–40 (2010). https://doi.org/10.1038/nbt0110-38

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