Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Laser surgery for mouse geneticists

A rapid, new approach for generating mutant mice from embryonic stem cells may accelerate high-throughput phenotype analysis.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Comparison of homozygous mutant mouse production by conventional and laser-assisted microinjection procedures.

Kim Caesar

References

  1. Austin, C.P. et al. Nat. Genet. 36, 921–924 (2004).

    CAS  Article  Google Scholar 

  2. Auwerx, J. et al. Nat. Genet. 36, 925–927 (2004).

    CAS  Article  Google Scholar 

  3. Poueymirou, W.T. et al. Nat. Biotechnol. 25, 91–99 (2007).

    CAS  Article  Google Scholar 

  4. Eggan, K. et al. Nat. Biotechnol. 20, 455–459 (2002).

    CAS  Article  Google Scholar 

  5. Tokunaga, T. & Tsunoda, Y. Dev. Growth Differ. 34, 561–566 (1992).

    Article  Google Scholar 

  6. Mortensen, R.M., Conner, D.A., Chao, S., Geisterfer-Lowrance, A.A. & Seidman, J.G. Mol. Cell. Biol. 12, 2391–2395 (1992).

    CAS  Article  Google Scholar 

  7. Abuin, A. & Bradley, A. Mol. Cell. Biol. 16, 1851–1856 (1996).

    CAS  Article  Google Scholar 

  8. Brook, F.A. & Gardner, R.L. Proc. Natl. Acad. Sci. USA 94, 5709–5712 (1997).

    CAS  Article  Google Scholar 

  9. Schoonjans, L. et al. Stem Cells 21, 90–97 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gridley, T., Woychik, R. Laser surgery for mouse geneticists. Nat Biotechnol 25, 59–60 (2007). https://doi.org/10.1038/nbt0107-59

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0107-59

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing