Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Sorting out metagenomes

Nature Biotechnology volume 23, pages 38–39 (2005)Cite this article

An ingenious screening method exploiting substrate induction of gene expression provides a rapid means of identifying new catabolic pathways in unculturable microorganisms.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Scheme for constructing and screening metagenomic libraries.

Bob Crimi

References

  1. Pace, N.R. Science 276, 734–740 (1997).

    Article  CAS  Google Scholar 

  2. Uchiyama, T., Abe, T., Ikemura, T. & Watanabe, K. Nat. Biotechnol. 23, 88–93 (2005).

    Article  CAS  Google Scholar 

  3. Handelsman, J., Rondon, M.R., Brady, S.F., Clardy, J. & Goodman, R.M. Chem. Biol. 5, R245–249 (1998).

    Article  CAS  Google Scholar 

  4. Healy, F.G. et al. Appl. Microbiol. Biotechnol. 43, 667–674 (1995).

    Article  CAS  Google Scholar 

  5. Stein, J.L., Marsh, T.L., Wu, K.Y., Shizuya, H. & DeLong, E.F. J. Bacteriol. 178, 591–599 (1996).

    Article  CAS  Google Scholar 

  6. Beja, O. et al. Science 289, 1902–1906 (2000).

    Article  CAS  Google Scholar 

  7. Tyson, G.W. et al. Nature 428, 37–43 (2004).

    Article  CAS  Google Scholar 

  8. Henne, A., Daniel, R., Schmitz, R.A. & Gottschalk, G. Appl. Environ. Microbiol. 65, 3901–3907 (1999).

    Article  CAS  Google Scholar 

  9. Diaz-Torres, M.L. et al. Antimicrob. Agents Chemother. 47, 1430–1432 (2003).

    Article  CAS  Google Scholar 

  10. Handelsman, J. Micro. Molec. Biol. Rev. 68, 669–685 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Plant Pathology, University of Wisconsin, 1630 Linden Drive, Madison, 53706, Wisconsin, USA

    Jo Handelsman

Authors
  1. Jo Handelsman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Handelsman, J. Sorting out metagenomes. Nat Biotechnol 23, 38–39 (2005). https://doi.org/10.1038/nbt0105-38

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0105-38

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing