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Old dogma, new tricks—21st Century phage therapy

As antibiotic resistant bacteria threaten a public health crisis, biotechnology is turning to bacteriophages, nature's tiniest viruses. But can phage therapy overcome its historical baggage?

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Figure 1: Phage life cycle.

R. Henretta

Figure 2: Phage pioneers.
Figure 3: Lysis to kill.


  1. US Centers for Disease Control, the Food and Drug Administration and the US National Institutes of Health. A Public Health Action Plan to Combat Antimicrobial Resistance (CDC, FDA & NIH, June, 2000) ( actionplan/aractionplan.pdf).

  2. S. Tslodras et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 358, 207–208 (2001).

    Article  Google Scholar 

  3. G.M. Eliopoulos, et al. Characterization of vancomycin-resistant Enterococcus faecium isolates from the United States and their susceptibility in vitro to dalfopristin-quinupristin. Antimicrobial Agents Chemother. 42, 1088–1092 (1998).

    CAS  Article  Google Scholar 

  4. Fox, J. Concerns raised over declining antiinfective R&D. Nat. Biotechnol. 21, 1255–1256 (2003).

    CAS  Article  Google Scholar 

  5. Scholl, D. et al. Bacteriophage K1-5 encodes two different tail fiber proteins, allowing it to infect and replicate on both K1 and K5 strains of Escherichia coli. J. Virol. 75, 2509–2515 (2001).

    CAS  Article  Google Scholar 

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Thiel, K. Old dogma, new tricks—21st Century phage therapy. Nat Biotechnol 22, 31–36 (2004).

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