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Old dogma, new tricks—21st Century phage therapy

Nature Biotechnology volume 22, pages 3136 (2004) | Download Citation

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As antibiotic resistant bacteria threaten a public health crisis, biotechnology is turning to bacteriophages, nature's tiniest viruses. But can phage therapy overcome its historical baggage?

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References

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    US Centers for Disease Control, the Food and Drug Administration and the US National Institutes of Health. A Public Health Action Plan to Combat Antimicrobial Resistance (CDC, FDA & NIH, June, 2000) ().

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    et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 358, 207–208 (2001).

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    , et al. Characterization of vancomycin-resistant Enterococcus faecium isolates from the United States and their susceptibility in vitro to dalfopristin-quinupristin. Antimicrobial Agents Chemother. 42, 1088–1092 (1998).

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    Concerns raised over declining antiinfective R&D. Nat. Biotechnol. 21, 1255–1256 (2003).

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    et al. Bacteriophage K1-5 encodes two different tail fiber proteins, allowing it to infect and replicate on both K1 and K5 strains of Escherichia coli. J. Virol. 75, 2509–2515 (2001).

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  1. Karl Thiel is a freelance writer based in Portland, Oregon, USA.

    • Karl Thiel

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DOI

https://doi.org/10.1038/nbt0104-31

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