Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The sigmoidal curve of cancer

Nature Biotechnology volume 21, pages 13–14 (2003)Cite this article

An Erratum to this article was published on 01 February 2003

This article has been updated

A growing list of papers supports a role for aneuploidy in the genetic underpinning of malignant transformation2. Of particular significance is a paper published last year by the Duesberg group3 that comes very close to showing the existence of hitherto elusive, stage-specific chromosomal combinations (aneusomies). It does so by clearly demonstrating that particular aneusomies appear in nitrosomethylurea-transformed Chinese hamster cells in vitro, and in tumors derived from these cells in vivo, with a much higher frequency than would be expected based on random chromosome shuffling. For example, 79% of in vitro–transformed cells were trisomic for chromosome 3, and 59% were monosomic for chromosome 10; moreover, 52% of the transformed cells shared trisomy 3 and monosomy 10, much higher than the 0.6% expected if the aneusomies were the result of random chromosomal imbalances.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

Change history

  • 07 January 2003

    Full text has footnote, PDF has been appended with erratum (this text not included in erratum as is standard

Notes

  1. Note: Page 13, the text in the first paragraph of column 3 "that, the notion that the evolution of aneuploid malignant cells is chaotic…" is incorrect. The correct text is below: "that the evolution of aneuploid malignant cells is chaotic…"

    Nature Biotechnology regrets this error.

References

  1. Marx, J. Science 297, 544–546 (2002).

    CAS  Article  Google Scholar 

  2. Bialy, H. Nat. Biotechnol. 19, 22–23 (2001).

    CAS  Article  Google Scholar 

  3. Fabarius, A., Willer, A., Yerganian, G., Hehlmann, R. & Duesberg, P. Proc. Natl. Acad. Sci. USA 99, 6778–6783 (2002).

    CAS  Article  Google Scholar 

  4. Li, R. et al. Proc. Natl. Acad. Sci. USA 94, 14506–14511 (1997).

    CAS  Article  Google Scholar 

  5. Duesberg, P., Rausch, C., Rasnick, D. & Hehlmann, R. Proc. Natl. Acad. Sci. USA 95, 13692–13697 (1998).

    CAS  Article  Google Scholar 

  6. Duesberg, P., Stindl, R. & Hehlmann, R. Proc. Natl. Acad. Sci. USA, 98, 11283–11288 (2001).

    CAS  Article  Google Scholar 

  7. Rasnick, D. Biochem. J. 348, 497–506 (2000).

    CAS  Article  Google Scholar 

  8. Rasnick, D. & Duesberg, P.H. Biochem. J. 340, 621–630 (1999).

    CAS  Article  Google Scholar 

  9. Rasnick, D. Cancer Genet. Cytogenet. 135, 66–72 (2002).

    Article  Google Scholar 

  10. Duesberg, P. & Rasnick, D. Cell Motil. Cytoskel. 47, 81–107 (2000).

    CAS  Article  Google Scholar 

  11. Zhang, L. et al. Science 276, 1268–1272 (1997).

    CAS  Article  Google Scholar 

  12. Pollack, J.R. et al. Proc. Natl. Acad. Sci. USA 99, 12963–12968 (2002).

    CAS  Article  Google Scholar 

  13. Nowak, M.A. et al. Proc. Natl. Acad. Sci. USA 99, 16226–16231 (2002).

    CAS  Article  Google Scholar 

  14. Jallepalli, P.V. & Lengauer, C. Nat. Rev. Cancer 1, 109–117 (2001).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. research scientist at the Institute of Biotechnology, Autonomous National University of Mexico (IBT/UNAM), Cuernavaca, Mexico

    Roberto P. Stock

  2. resident scholar at IBT/UNAM, and the founding scientific editor of Nature Biotechnology

    Harvey Bialy

Authors
  1. Roberto P. Stock
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harvey Bialy
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Stock, R., Bialy, H. The sigmoidal curve of cancer. Nat Biotechnol 21, 13–14 (2003). https://doi.org/10.1038/nbt0103-13

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0103-13

Further reading

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing