Supplementary Figure 8: Representative placental histology of mice treated with PBS, hsiRNA 2383 and 2283/2519 (2 × 20 mg/kg, IV, n = 4), showing anti-CD31 staining. | Nature Biotechnology

Supplementary Figure 8: Representative placental histology of mice treated with PBS, hsiRNA 2383 and 2283/2519 (2 × 20 mg/kg, IV, n = 4), showing anti-CD31 staining.

From: RNAi modulation of placental sFLT1 for the treatment of preeclampsia

Supplementary Figure 8

PBS treated placental labyrinth shows extensive staining for CD31 (upper panel), suggesting robust vascular network. Under higher magnifications (lower panel), PBS treated placental tissue displays small vessels filled with nucleated erythrocytes in close vicinity to maternal blood sinuses. There were no significant changes in the hsiRNA injected mice. D- decidua, Jz - junctional zone and L – labyrinth.

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