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Proteomics goes parallel

Nature Biotechnology volume 36, pages 1051–1053 (2018)Cite this article

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Massively parallel sequencing of peptides could signal a new era of high-throughput proteomics.

Proteomics has yet to attain the power of genomics and transcriptomics. The impressive performance of technologies for nucleic acid sequencing rests on massively parallel measurements of short oligonucleotides, using fluorescence as a readout. In this issue, Swaminathan et al.1 demonstrate that parallel fluorescence sequencing is also achievable for peptides. Their innovative method combines elements of classic protein chemistry with features of the optical systems used in nucleic acid sequencing. Although further optimization of the approach is needed, the study fascinates with the prospect of a generally accessible, reliable and truly universal proteomic technology.

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Figure 1: Peptide fluorosequencing as described by Swaminathan et al.1

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Authors and Affiliations

  1. Ben C. Collins and Ruedi Aebersold are in the Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.,

    Ben C Collins & Ruedi Aebersold

  2. Ruedi Aebersold is also in the Faculty of Science, University of Zurich, Zurich, Switzerland.,

    Ruedi Aebersold

Authors
  1. Ben C Collins
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  2. Ruedi Aebersold
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Correspondence to Ben C Collins or Ruedi Aebersold.

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The authors declare no competing financial interests.

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Collins, B., Aebersold, R. Proteomics goes parallel. Nat Biotechnol 36, 1051–1053 (2018). https://doi.org/10.1038/nbt.4288

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