Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News Feature
  • Published:

Small molecules get the message

A cadre of new biotechs have set their sights on targeting RNA with small-molecule drugs. Justin Petrone and Laura DeFrancesco report.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rizvi, N.F. et al. ACS Chem. Biol. 13, 820–831 (2018).

    Article  CAS  Google Scholar 

  2. Tran, T. & Disney, M.D. Nat. Commun. 3, 1125 (2012).

    Article  Google Scholar 

  3. Rzuczek, S.G. et al. Nat. Chem. Biol. 13, 188–193 (2017).

    Article  CAS  Google Scholar 

  4. Wang, J., Schultz, P.G. & Johnson, K.A. Proc. Natl. Acad. Sci. USA 115, E4604–E4612 (2018).

    Article  CAS  Google Scholar 

  5. Mustoe, A.M. et al. Cell 173, 181–195.e18 (2018).

    Article  CAS  Google Scholar 

  6. Palacino, J. et al. Nat. Chem. Biol. 11, 511–517 (2015).

    Article  CAS  Google Scholar 

  7. Seiler, M. et al. Nat. Med. 24, 497–504 (2018).

    Article  CAS  Google Scholar 

  8. Welch, E.M. et al. Nature 447, 87–91 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Petrone, J., DeFrancesco, L. Small molecules get the message. Nat Biotechnol 36, 787–790 (2018). https://doi.org/10.1038/nbt.4241

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.4241

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing