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Making the right calls in precision oncology

Expert curation at present remains the only reliable solution for interpretation of mutation information in the clinical practice of oncology.

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Figure 1: The typical workflow of precision data processing.
Figure 2: Number of unique variants in selected biomarkers curated for NSCLC patients by N-of-One, as of November 14, 2017.
Figure 3: Three primary approaches are being taken to scale and interpret the vast amount of tumor genetic data generated: crowdsourcing, AI, and expert curation.

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Correspondence to Kristen Lalowski.

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K.D.B., K.L., and S.K.E. are employees of N-of-One.

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Bungartz, K., Lalowski, K. & Elkin, S. Making the right calls in precision oncology. Nat Biotechnol 36, 692–696 (2018). https://doi.org/10.1038/nbt.4214

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