This is a preview of subscription content
Access options
Subscribe to Nature+
Get immediate online access to the entire Nature family of 50+ journals
$29.99
monthly
Subscribe to Journal
Get full journal access for 1 year
$99.00
only $8.25 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.



References
Magnúsdóttir, S. et al. Nat. Biotechnol. 35, 81–89 (2017).
Karlsson, F.H. et al. Nat. Commun. 3, 1245 (2012).
Karlsson, F.H. et al. Nature 498, 99–103 (2013).
Qin, J. et al. Nature 490, 55–60 (2012).
Forslund, K. et al. Nature 528, 262–266 (2015).
Karlsson, F.H., Nookaew, I., Petranovic, D. & Nielsen, J. Trends Biotechnol. 29, 251–258 (2011).
Mardinoglu, A. et al. Mol. Syst. Biol. 11, 834 (2015).
Shoaie, S. et al. Cell Metab. 22, 320–331 (2015).
Zomorrodi, A.R. & Maranas, C.D. PLoS Comput. Biol. 8, e1002363 (2012).
Harcombe, W.R. et al. Cell Rep. 7, 1104–1115 (2014).
King, Z.A. et al. Nucleic Acids Res. 44 D1, D515–D522 (2016).
Larhlimi, A., David, L., Selbig, J. & Bockmayr, A. BMC Bioinformatics 13, 57 (2012).
Albenberg, L. et al. Gastroenterology 147, 1055–1063.e8 (2014).
Espey, M.G. Free Radic. Biol. Med. 55, 130–140 (2013).
Acknowledgements
We acknowledge funding from the Novo Nordisk Foundation (NNF10CC1016517) and the Knut and Alice Wallenberg Foundation.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–11 and Supplementary Tables 1 and 2 (PDF 10901 kb)
Rights and permissions
About this article
Cite this article
Babaei, P., Shoaie, S., Ji, B. et al. Challenges in modeling the human gut microbiome. Nat Biotechnol 36, 682–686 (2018). https://doi.org/10.1038/nbt.4213
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt.4213
Further reading
-
Understanding the host-microbe interactions using metabolic modeling
Microbiome (2021)
-
An efficient and scalable top-down method for predicting structures of microbial communities
Nature Computational Science (2021)
-
Large-scale metabolic interaction network of the mouse and human gut microbiota
Scientific Data (2020)
-
Current status and applications of genome-scale metabolic models
Genome Biology (2019)
-
Modelling approaches for studying the microbiome
Nature Microbiology (2019)