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The 160K Natural Organism Library, a unique resource for natural products research

Nature Biotechnology volume 36, pages 570–573 (2018)Cite this article

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Figure 1: Composition of NOL at BII and its exploitation using four screening approaches.
Figure 2: Geographical distribution of NOL samples.

References

  1. Harvey, A.L., Edrada-Ebel, R. & Quinn, R.J. Nat. Rev. Drug Discov. 14, 111–129 (2015).

    CAS  Article  Google Scholar 

  2. Newman, D.J. & Cragg, G.M. Planta Med. 82, 775–789 (2016).

    CAS  Article  Google Scholar 

  3. Eisenhaber, F. J. Bioinform. Comput. Biol. 10, 1271001 (2012).

    Article  Google Scholar 

  4. Sheridan, C. Nat. Biotechnol. 30, 385–387 (2012).

    CAS  Article  Google Scholar 

  5. Cao, S., Rossant, C., Ng, S., Buss, A.D. & Butler, M.S. Phytochemistry 64, 987–990 (2003).

    CAS  Article  Google Scholar 

  6. Yoganathan, K. et al. J. Nat. Prod. 67, 1681–1684 (2004).

    CAS  Article  Google Scholar 

  7. Phoon, C.W. et al. Tetrahedron 60, 11619–11628 (2004).

    CAS  Article  Google Scholar 

  8. Cao, S. et al. J. Nat. Prod. 69, 707–709 (2006).

    CAS  Article  Google Scholar 

  9. Yoganathan, K. et al. Tetrahedron 64, 10181–10187 (2008).

    CAS  Article  Google Scholar 

  10. Janssen, C.O. et al. Bioorg. Med. Chem. Lett. 18, 5771–5773 (2008).

    CAS  Article  Google Scholar 

  11. Subramaniam, G., Ang, K.H., Ng, S.B., Buss, A.D. & Butler, M.S. Phytochem. Lett. 2, 88–90 (2009).

    CAS  Article  Google Scholar 

  12. Somanadhan, B. et al. J. Nat. Prod. 74, 1500–1502 (2011).

    CAS  Article  Google Scholar 

  13. Rho, J.R. et al. Org. Lett. 17, 1377–1380 (2015).

    CAS  Article  Google Scholar 

  14. Alt, S. & Wilkinson, B. ACS Chem. Biol. 10, 2468–2479 (2015).

    CAS  Article  Google Scholar 

  15. Jang, K.H. et al. Angew. Chem. Int. Edn Engl. 52, 7822–7824 (2013).

    CAS  Article  Google Scholar 

  16. Sirota, F.L. et al. J. Genomics 6, 63–73 (2018).

    Article  Google Scholar 

  17. Hert, J., Irwin, J.J., Laggner, C., Keiser, M.J. & Shoichet, B.K. Nat. Chem. Biol. 5, 479–483 (2009).

    CAS  Article  Google Scholar 

  18. Schenone, M., Dancˇík, V., Wagner, B.K. & Clemons, P.A. Nat. Chem. Biol. 9, 232–240 (2013).

    CAS  Article  Google Scholar 

  19. Lachance, H., Wetzel, S., Kumar, K. & Waldmann, H. J. Med. Chem. 55, 5989–6001 (2012).

    CAS  Article  Google Scholar 

  20. Sukuru, S.C. et al. J. Biomol. Screen. 14, 690–699 (2009).

    CAS  Article  Google Scholar 

  21. Choi, H. et al. J. Cheminform. 9, 2 (2017).

    Article  Google Scholar 

  22. Lewin, H.A. et al. Proc. Natl. Acad. Sci. USA 115, 4325–4333 (2018).

    CAS  Article  Google Scholar 

  23. Blin, K., Medema, M.H., Kottmann, R., Lee, S.Y. & Weber, T. Nucleic Acids Res. 45 D1, D555–D559 (2017).

    Article  Google Scholar 

  24. Eisenhaber, B. et al. Methods Mol. Biol. 1415, 477–506 (2016).

    CAS  Article  Google Scholar 

  25. Medema, M.H. & Osbourn, A. Nat. Prod. Rep. 33, 951–962 (2016).

    CAS  Article  Google Scholar 

  26. Yim, G., Wang, W., Thaker, M.N., Tan, S. & Wright, G.D. ACS Infect. Dis. 2, 642–650 (2016).

    CAS  Article  Google Scholar 

  27. Wink, J. Microbiol. Aust. 32, 81–85 (2011).

    Google Scholar 

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Acknowledgements

The authors are grateful for A*STAR's basic financial support for the NOL.

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Author notes

  1. Siew Bee Ng and Yoganathan Kanagasundaram: These authors contributed equally to this work.

Authors and Affiliations

  1. Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore

    Siew Bee Ng, Yoganathan Kanagasundaram, Hao Fan, Prakash Arumugam, Birgit Eisenhaber & Frank Eisenhaber

  2. School of Computer Engineering, Nanyang Technological University (NTU), Singapore, Republic of Singapore

    Frank Eisenhaber

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  1. Siew Bee Ng
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  2. Yoganathan Kanagasundaram
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Correspondence to Siew Bee Ng or Frank Eisenhaber.

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Ng, S., Kanagasundaram, Y., Fan, H. et al. The 160K Natural Organism Library, a unique resource for natural products research. Nat Biotechnol 36, 570–573 (2018). https://doi.org/10.1038/nbt.4187

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