The 160K Natural Organism Library, a unique resource for natural products research

Nature Biotechnology volume 36, pages570–573(2018)Cite this article

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Figure 1: Composition of NOL at BII and its exploitation using four screening approaches.
Figure 2: Geographical distribution of NOL samples.

References

  1. 1

    Harvey, A.L., Edrada-Ebel, R. & Quinn, R.J. Nat. Rev. Drug Discov. 14, 111–129 (2015).

  2. 2

    Newman, D.J. & Cragg, G.M. Planta Med. 82, 775–789 (2016).

  3. 3

    Eisenhaber, F. J. Bioinform. Comput. Biol. 10, 1271001 (2012).

  4. 4

    Sheridan, C. Nat. Biotechnol. 30, 385–387 (2012).

  5. 5

    Cao, S., Rossant, C., Ng, S., Buss, A.D. & Butler, M.S. Phytochemistry 64, 987–990 (2003).

  6. 6

    Yoganathan, K. et al. J. Nat. Prod. 67, 1681–1684 (2004).

  7. 7

    Phoon, C.W. et al. Tetrahedron 60, 11619–11628 (2004).

  8. 8

    Cao, S. et al. J. Nat. Prod. 69, 707–709 (2006).

  9. 9

    Yoganathan, K. et al. Tetrahedron 64, 10181–10187 (2008).

  10. 10

    Janssen, C.O. et al. Bioorg. Med. Chem. Lett. 18, 5771–5773 (2008).

  11. 11

    Subramaniam, G., Ang, K.H., Ng, S.B., Buss, A.D. & Butler, M.S. Phytochem. Lett. 2, 88–90 (2009).

  12. 12

    Somanadhan, B. et al. J. Nat. Prod. 74, 1500–1502 (2011).

  13. 13

    Rho, J.R. et al. Org. Lett. 17, 1377–1380 (2015).

  14. 14

    Alt, S. & Wilkinson, B. ACS Chem. Biol. 10, 2468–2479 (2015).

  15. 15

    Jang, K.H. et al. Angew. Chem. Int. Edn Engl. 52, 7822–7824 (2013).

  16. 16

    Sirota, F.L. et al. J. Genomics 6, 63–73 (2018).

  17. 17

    Hert, J., Irwin, J.J., Laggner, C., Keiser, M.J. & Shoichet, B.K. Nat. Chem. Biol. 5, 479–483 (2009).

  18. 18

    Schenone, M., Dancˇík, V., Wagner, B.K. & Clemons, P.A. Nat. Chem. Biol. 9, 232–240 (2013).

  19. 19

    Lachance, H., Wetzel, S., Kumar, K. & Waldmann, H. J. Med. Chem. 55, 5989–6001 (2012).

  20. 20

    Sukuru, S.C. et al. J. Biomol. Screen. 14, 690–699 (2009).

  21. 21

    Choi, H. et al. J. Cheminform. 9, 2 (2017).

  22. 22

    Lewin, H.A. et al. Proc. Natl. Acad. Sci. USA 115, 4325–4333 (2018).

  23. 23

    Blin, K., Medema, M.H., Kottmann, R., Lee, S.Y. & Weber, T. Nucleic Acids Res. 45 D1, D555–D559 (2017).

  24. 24

    Eisenhaber, B. et al. Methods Mol. Biol. 1415, 477–506 (2016).

  25. 25

    Medema, M.H. & Osbourn, A. Nat. Prod. Rep. 33, 951–962 (2016).

  26. 26

    Yim, G., Wang, W., Thaker, M.N., Tan, S. & Wright, G.D. ACS Infect. Dis. 2, 642–650 (2016).

  27. 27

    Wink, J. Microbiol. Aust. 32, 81–85 (2011).

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Acknowledgements

The authors are grateful for A*STAR's basic financial support for the NOL.

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Author notes

  1. Siew Bee Ng and Yoganathan Kanagasundaram: These authors contributed equally to this work.

Affiliations

  1. Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore

    • Siew Bee Ng
    • , Yoganathan Kanagasundaram
    • , Hao Fan
    • , Prakash Arumugam
    • , Birgit Eisenhaber
    •  & Frank Eisenhaber

  2. School of Computer Engineering, Nanyang Technological University (NTU), Singapore, Republic of Singapore

    • Frank Eisenhaber

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Correspondence to Siew Bee Ng or Frank Eisenhaber.

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Ng, S., Kanagasundaram, Y., Fan, H. et al. The 160K Natural Organism Library, a unique resource for natural products research. Nat Biotechnol 36, 570–573 (2018) doi:10.1038/nbt.4187

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