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Patent mining and landscaping of emerging recombinant factor VIII through network analysis

Nature Biotechnology volume 36, pages 585–590 (2018)Cite this article

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A landscape analysis of the recombinant factor VIII patent sector using network analysis to map the cooperation network among assignees shows emerging technologies that focus on improved methods for rFVIII production and bioactivity performance.

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Figure 1: New FVIII molecules targeting increased half-life by the first report year.
Figure 2: Publication trend and geographical coverage of rFVIII patents.
Figure 3: The top 15 inventors and assignees of patents related to rFVIII.
Figure 4: Cooperation network among assignees of rFVIII patents.
Figure 5: Analysis of patent documents content by text clustering and ThemeScape.
Figure 6: Patent citation network of rFVIII inventions and its main path.

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Acknowledgements

This study is supported by research funds from São Paulo Research Foundation – FAPESP grant number 2012/22686-9; 2014/22500-8; 2015/13816-4; 2013/08135-2 and 2016/02433-0.

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Authors and Affiliations

  1. School of Economics, Business Administration and Accounting, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

    Cristiano Gonçalves Pereira & Geciane Silveira Porto

  2. Center for Cell-based Therapy CTC, Regional Blood Center of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

    Virgínia Picanco-Castro & Dimas Tadeu Covas

  3. Institute of Advanced Studies of the University of São Paulo IEA/USP, Ribeirão Preto, São Paulo, Brazil

    Geciane Silveira Porto

Authors
  1. Cristiano Gonçalves Pereira
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  2. Virgínia Picanco-Castro
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  3. Dimas Tadeu Covas
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  4. Geciane Silveira Porto
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Corresponding author

Correspondence to Geciane Silveira Porto.

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Supplementary Figures 1–4, Supplementary Tables 1–3 and Supplementary Methods (PDF 687 kb)

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Pereira, C., Picanco-Castro, V., Covas, D. et al. Patent mining and landscaping of emerging recombinant factor VIII through network analysis. Nat Biotechnol 36, 585–590 (2018). https://doi.org/10.1038/nbt.4178

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