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Patent mining and landscaping of emerging recombinant factor VIII through network analysis

A landscape analysis of the recombinant factor VIII patent sector using network analysis to map the cooperation network among assignees shows emerging technologies that focus on improved methods for rFVIII production and bioactivity performance.

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Figure 1: New FVIII molecules targeting increased half-life by the first report year.
Figure 2: Publication trend and geographical coverage of rFVIII patents.
Figure 3: The top 15 inventors and assignees of patents related to rFVIII.
Figure 4: Cooperation network among assignees of rFVIII patents.
Figure 5: Analysis of patent documents content by text clustering and ThemeScape.
Figure 6: Patent citation network of rFVIII inventions and its main path.


  1. Srivastava, A. et al. Haemophilia 19, e1–e47 (2013).

    Article  CAS  Google Scholar 

  2. Tiede, A. et al. J. Thromb. Haemost. 11, 670–678 (2013).

    Article  CAS  Google Scholar 

  3. Konkle, B.A. et al. Blood 126, 1078–1085 (2015).

    Article  CAS  Google Scholar 

  4. Mahlangu, J. et al. Blood 123, 317–325 (2014).

    Article  CAS  Google Scholar 

  5. Zollner, S.B. et al. Thromb. Res. 132, 280–287 (2013).

    Article  CAS  Google Scholar 

  6. Uchida, N. et al. Blood 127, 1633–1641 (2016).

    Article  CAS  Google Scholar 

  7. Pabinger-Fasching, I. & Négrier, C. Thromb. Res. 141 Suppl 3, S1 (2016).

    Article  CAS  Google Scholar 

  8. Cantner, U. & Graf, H. Res. Policy 35, 463–480 (2006).

    Article  Google Scholar 

  9. Owen, R., Macnaghten, P. & Stilgoe, J. Sci. Public Policy 39, 751–760 (2012).

    Article  Google Scholar 

  10. Van Der Valk, T. & Gijsbers, G. Innov. Manag. Policy Pract. 12, 5–17 (2010).

    Article  Google Scholar 

  11. Trajtenberg, M. Rand J. Econ. 21, 172–187 (1990).

    Article  Google Scholar 

  12. Jaffe, A.B. & Trajtenberg, M. Patents, Citations & Innovations: a Window on the Knowledge Economy (MIT, 2002).

    Google Scholar 

  13. Narin, F. Scientometrics 30, 147–155 (1994).

    Article  Google Scholar 

  14. Karki, M.M.S. World Pat. Inf. 19, 269–272 (1997).

    Article  Google Scholar 

  15. Verspagen, B. Adv. Complex Syst. 10, 93–115 (2007).

    Article  Google Scholar 

  16. Fontana, R., Nuvolari, A. & Verspagen, B. Econ. Innov. New Technol. 18, 311–336 (2009).

    Article  Google Scholar 

  17. Porto, G.S., Kannebley, S., Jr. & Baroni, J.P.M.T. in Economia de Baixo Carbono: Impactos de Novos Marcos Regulatórios e Tecnológicos sobre a Economia Brasileira, (eds. Toneto, Jr., R. & Pinho, M.) 452 (FUNPEC-Editora, 2017).

    Google Scholar 

  18. Roberts, M. et al. Nat. Biotechnol. 32, 742–748 (2014).

    Article  CAS  Google Scholar 

  19. Egelie, K.J., Graff, G.D., Strand, S.P. & Johansen, B. Nat. Biotechnol. 34, 1025–1031 (2016).

    Article  CAS  Google Scholar 

  20. Régibeau, P. & Rockett, K. CEPR Discussion Paper No. 6178. (2007).

  21. Popp, D., Juhl, T. & Johnson, D.K.N. Top. Econ. Anal. Policy 4, 1–48 (2004).

    Google Scholar 

  22. World Federation of Hemophilia. World Federation of Hemophilia Report on the Annual Global Survey 2014 (World Federation of Hemophilia, 2015).

  23. Bihari, A. & Pandia, M.K. in 2015 International Conference on Futuristic Trends on Computational Analysis and Knowledge Management (ABLAZE) 510–514 (IEEE, 2015).

    Book  Google Scholar 

  24. Dumont, J.A. et al. Blood 119, 3024–3030 (2012).

    Article  CAS  Google Scholar 

  25. Schellenberger, V. et al. Nat. Biotechnol. 27, 1186–1190 (2009).

    Article  CAS  Google Scholar 

  26. Drager, D. et al. Blood 126, 3492 (2015).

    Article  Google Scholar 

  27. Érdi, P. et al. Scientometrics 95, 225–242 (2013).

    Article  Google Scholar 

  28. Hummon, N.P. & Dereian, P. Soc. Networks 11, 39–63 (1989).

    Article  Google Scholar 

  29. Astermark, J. et al. Blood 109, 546–551 (2007).

    Article  CAS  Google Scholar 

  30. Young, G. & Mahlangu, J.N. Haemophilia 22 Suppl 5, 25–30 (2016).

    Article  Google Scholar 

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This study is supported by research funds from São Paulo Research Foundation – FAPESP grant number 2012/22686-9; 2014/22500-8; 2015/13816-4; 2013/08135-2 and 2016/02433-0.

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Correspondence to Geciane Silveira Porto.

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The authors declare no competing financial interests.

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Supplementary Figures 1–4, Supplementary Tables 1–3 and Supplementary Methods (PDF 687 kb)

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Pereira, C., Picanco-Castro, V., Covas, D. et al. Patent mining and landscaping of emerging recombinant factor VIII through network analysis. Nat Biotechnol 36, 585–590 (2018).

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