(a) Sankey plots showing bi-partite information flow between CD4+ T-cell subsets and a variety of cytokines. (b) A sorted histogram illustrating the number of unique cell-types secreting each of the 114 cytokines (outgoing interactions). A second y-axis displays the information as a cumulative sum (blue line). 50% of outgoing edges are attributed to only 17 (15%) cytokines (grey area). Cytokine family classification appears as coloring of individual members along x-axis. (c) Scatter plot highlighting the strong correlation in cytokine degrees between incoming and outgoing directions of the manually curated reference book interaction network (n=104 cytokines, r=0.69 pval<0.001, Pearson's).