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Brain organoids get vascularized

Transplantation of cerebral organoids into the mouse brain overcomes some limitations of in vitro systems.

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Figure 1: Comparison of brain organoids grown in vitro and transplanted into the mouse cortex.

Marina Corral Spence / Springer Nature

References

  1. 1

    Lancaster, M.A. et al. Nature 501, 373–379 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. 2

    Mansour, A.A. et al. Nat. Biotechnol. 36, 432–441 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. 3

    DeFelipe, J. Front. Neuroanat. 5 (2011).

  4. 4

    Kelava, I. & Lancaster, M.A. Cell Stem Cell 18, 736–748 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. 5

    Kadoshima, T. et al. Proc. Natl. Acad. Sci. USA. 110, 20284–20289 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. 6

    Lancaster, M.A. et al. Nat. Biotechnol. 35, 659–666 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. 7

    Kilb, W., Kirischuk, S. & Luhmann, H.J. Eur. J. Neurosci. 34, 1677–1686 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  8. 8

    Quadrato, G. et al. Nature 545, 48–53 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. 9

    Takebe, T. et al. Nature 499, 481–484 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. 10

    Smith, Q. & Gerecht, S. Curr. Opin. Chem. Eng. 3, 42–50 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  11. 11

    van den Berg, C.W. et al. Stem Cell Rep. 10, 751–765 (2018).

    Article  Google Scholar 

Download references

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Correspondence to Madeline A Lancaster.

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Lancaster, M. Brain organoids get vascularized. Nat Biotechnol 36, 407–408 (2018). https://doi.org/10.1038/nbt.4133

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