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The evidence gap

Why digitally powered real-world evidence is the fix needed for our broken clinical trials system.

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Figure 1: Three influencers of response to therapy: biology, healthcare practices (HCPs) and behavior.


  1. 1

    Carls, G.S. et al. Diabetes Care 40, 1469–1478 (2017).

    CAS  Article  Google Scholar 

  2. 2

    Apple ResearchKit and CareKit. (2017).

  3. 3

    Williams, R. et al. Arthritis Rheumatol. 69, (suppl 10) (2017).

  4. 4

    Neff, G. & Nafus, D. Self-tracking (MIT Press, 2016).

    Book  Google Scholar 

  5. 5

    Herrmann, L.K. & Kim, J. mHealth 3, 2 (2017).

    Article  Google Scholar 

  6. 6

    Roess, A. N. Engl. J. Med. 377, 2010–2011 (2017).

    Article  Google Scholar 

  7. 7

    Miseta, E. Clinical Leader (2017).

Download references

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Corresponding author

Correspondence to Vicki Seyfert-Margolis.

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Competing interests

CEO and Founder of MyOwnMed, a company engaged in using its own software platform and digital tools for real-world evidence studies with academia and industry.

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Seyfert-Margolis, V. The evidence gap. Nat Biotechnol 36, 228–232 (2018).

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