Driving T-cell immunotherapy to solid tumors

T cell receptor (TCR) gene therapy can target the immune system to solid tumors in ways CAR-T cells can't match, but the field is still looking for a clear success. Ken Garber reports.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Dueling T-cell receptors.

References

  1. 1

    Yanagi, Y. et al. Nature 308, 145–149 (1984).

  2. 2

    Hedrick, S.M., Cohen, D.I., Nielsen, E.A. & Davis, M.M. Nature 308, 149–153 (1984).

  3. 3

    Dembić, Z. et al. Nature 320, 232–238 (1986).

  4. 4

    Morgan, R.A. et al. Science 314, 126–129 (2006).

  5. 5

    Holler, P.D. et al. Proc. Natl. Acad. Sci. USA 97, 5387–5392 (2000).

  6. 6

    Robbins, P.F. et al. J. Clin. Oncol. 29, 917–924 (2011).

  7. 7

    Parkhurst, M.R. et al. Mol. Ther. 19, 620–626 (2011).

  8. 8

    Morgan, R.A. et al. J. Immunother. 36, 133–151 (2013).

  9. 9

    Linette, G.P. et al. Blood 122, 863–871 (2013).

  10. 10

    Schmitt, T.M. et al. Blood 122, 348–356 (2013).

  11. 11

    Mackall, C. et al. J. Clin. Oncol. 35, suppl; abstr. 3000 (2017).

  12. 12

    Lu, Y.C. et al. Clin. Cancer Res. 20, 3401–3410 (2014).

  13. 13

    Tran, E. et al. Science 344, 641–645 (2014).

  14. 14

    Deniger, D.C. et al. Mol. Ther. 24, 1078–1089 (2016).

  15. 15

    Oda, S.K. et al. Blood 130, 2410–2419 (2017).

  16. 16

    Corrales, L., McWhirter, S.M., Dubensky, T.W. Jr. & Gajewski, T.F. J. Clin. Invest. 126, 2404–2411 (2016).

  17. 17

    Roybal, K.T. et al. Cell 164, 770–779 (2016).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Garber, K. Driving T-cell immunotherapy to solid tumors. Nat Biotechnol 36, 215–219 (2018) doi:10.1038/nbt.4090

Download citation

Further reading